> can anyone give me any advise
Not sure from your description exactly what they are but, as a breed, Dogues can be prone to the odd skin problem. You can try giving her liquidised raw spinach, that's good for skin and coat. I mix mine with some liquidised carrot or pear as my Dogues seem to eat it better that way. And you could try giving her a coat supplement like Quistel Omega 3. A teaspoonful a day should help.
Also as has been suggested, you could give her a bath, perhaps in something like Hibiscrub. I actually use Mediscrub these days from our vets as it's less drying but still antibacterial. It might help calm her skin down.
Good luck with your Dogue. They are very addictive and you may find that one is not enough ...